An HNF4α-miRNA Inflammatory Feedback Circuit Regulates Hepatocellular Oncogenesis
نویسندگان
چکیده
منابع مشابه
An HNF4α-miRNA Inflammatory Feedback Circuit Regulates Hepatocellular Oncogenesis
Hepatocyte nuclear factor 4α (HNF4α) is essential for liver development and hepatocyte function. Here, we show that transient inhibition of HNF4α initiates hepatocellular transformation through a microRNA-inflammatory feedback loop circuit consisting of miR-124, IL6R, STAT3, miR-24, and miR-629. Moreover, we show that, once this circuit is activated, it maintains suppression of HNF4α and sustai...
متن کاملAn HNF4a-miRNA Inflammatory Feedback Circuit Regulates Hepatocellular Oncogenesis
Maria Hatziapostolou,1,2 Christos Polytarchou,1,2 Eleni Aggelidou,4 Alexandra Drakaki,5 George A. Poultsides,6 Savina A. Jaeger,7 Hisanobu Ogata,8 Michael Karin,8 Kevin Struhl,3 Margarita Hadzopoulou-Cladaras,4,9 and Dimitrios Iliopoulos1,2,9,* 1Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute 2Department of Microbiology and Immunobiology 3Department of Biological Chemistr...
متن کاملA double-negative feedback loop between Wnt-β-catenin signaling and HNF4α regulates epithelial-mesenchymal transition in hepatocellular carcinoma.
Wnt-β-catenin signaling participates in the epithelial-mesenchymal transition (EMT) in a variety of cancers; however, its involvement in hepatocellular carcinoma (HCC) and downstream molecular events is largely undefined. HNF4α is the most prominent and specific factor maintaining the differentiation of hepatic lineage cells and a potential EMT regulator in HCC cells. However, the molecular mec...
متن کاملMutual amplification of HNF4α and IL-1R1 composes an inflammatory circuit in Helicobacter pylori associated gastric carcinogenesis
Helicobacter pylori (Hp) is an environmental inducer of gastritis and gastric cancer (GC). The immune response to Hp and the associated changes in somatic gene expression are key determinants governing the transition from gastritis to GC. We show that hepatocyte nuclear factor 4α (HNF4α) is upregulated by Hp infection via NF-κB signaling and that its protein and mRNA levels are elevated in GC. ...
متن کاملSUMOylation of HNF4α regulates protein stability and hepatocyte function
The coordination of signalling pathways within the cell is vital for normal human development and post-natal tissue homeostasis. Gene expression and function is therefore tightly controlled at a number of levels. We investigated the role that post-translational modifications play during human hepatocyte differentiation. In particular, we examined the role of the small ubiquitin-like modifier (S...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cell
سال: 2011
ISSN: 0092-8674
DOI: 10.1016/j.cell.2011.10.043